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Jinshu Yang
Lab Manager

    Hi, I am Jinshu. I am the Hallam lab manager. I like my job since it gives me a great opportunity to learn, to use different kinds of techniques, and to work with other people. I enjoy solving problems with my colleagues and we always become good friends.

Research interests and Projects:
I help with almost every project that goes on in the lab, but I do have my own research that focuses on the structure and function of serpin homologues derived from the mesophilic crenarchaeote Cenarchaeum symbiosum. Surveys of microbial genomes identified serpins in 6 archaeal and 23 bacterial genera. While the majority of microbial serpins exist as single copy genes, several bacterial and archaeal genomes harbour two or more copies. Most notably among this cohort is the genome of the mesophilic crenarchaeote C. symbiosum, in which five serpin homologues were identified. All five cluster with mammalian anti-thrombin, a secreted serine protease inhibitor, and serpins of unknown specificity identified in the methanogenic archaeon Methanosarcina acetivorans. Studies to assess their functional and structural properties promise to enhance our understanding of serpin evolution with the possibility of uncovering novel forms of inhibition or regulation.

Education:  
1995-1998 Capital University of Medical Science, Beijing, China. MSc
1988-1993 Shandong Medical University, China. M.D.

Work Experience:  
2006-present Department of Microbiology and Immunology, University of British Columbia
2004-2006 Medical Oncology Department, Institute of Cancer, Queen Mary University, London, UK
2002-2003 Department of Molecular and Cellular Biochemistry, Ohio State University, USA

Publications:

Lu YJ, Yang J, Noel E, Skoulakis S, Chaplin T, Raghavan M, Purkis T, McIntyre A, Kudahetti SC, Naase M, Berney D, Shipley J, Oliver RT, Young BD. Association between large-scale genomic homozygosity without chromosomal loss and nonseminomatous germ cell tumor development. Cancer Res. 2005 Oct 15;65(20):9137-41.

Yang J, Wilson C, Strefford JC, Summersgill B, Young BD, Shipley J, Oliver T, Lu YJ. Overexpression of genes on 16q associated with cisplatin resistance of testicular germ cell tumor cell lines. Genes Chromosomes Cancer. 2005 Jun;43(2):211-6.

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