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Research > Genomics of Rhodococcus sp. RHA1

A collaborative genomic project investigating Rhodococcus sp. RHA1 was recently initiated. This project involves Julian Davies, Lindsay Eltis and myself. Rhodococci are aerobic, gram-positive actinomycetes of high G+C content, capable of morphological differentiation in response to their environment (e.g., cocci or filaments). These widely occurring organisms are of considerable environmental and biotechnological importance due to their unique and diverse metabolic capabilities. These capabilities have pharmaceutical, environmental, chemical and energy applications. Goals of the project include elucidating metabolic networks of RHA1 and their regulation as well as elucidating responses of RHA1 to environmental conditions. This work will enable a much improved understanding of the ecology of RHA1 and related organisms and will greatly facilitate metabolic engineering of RHA1 for the above applications. The RHA1 genome sequence is being determined in collaboration with the Genome Sequence Center. We are undertaking functional genomic studies of RHA1 using DNA microarrays and proteomic methods. This project is funded by Genome Canada and Genome BC.

Rhodococcus RHA1
Branched filamentous growth of Rhodococcus sp. RHA1

Selected publications:
Martin, V.J.J. & W.W. Mohn. 2000. Genetic investigation of the catabolic pathway for the degradation of abietane diterpenoids by Pseudomonas abietaniphila BKME-9. J. Bacteriol. 182:3784-3793.
Martin, V.J.J. & W.W. Mohn. 1999. Recent advances in understanding resin acid biodegradation: microbial diversity and metabolism. Arch. Microbiol. 172:131-138.

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